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Progesterone Receptor Membrane Component 1080p

progesterone receptor membrane component 1080p

 

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6e8412f8ec

Activity...recording...is...turned...off....93..(5):..131426...^...a...b...Hand...RA,...Craven...RJ...(Oct...2003)....Reproduction....Our...results...support...the...assumption...that...mPR...represents...the...first...steroid...membrane...receptor...or...a...part...of...it...involved...in...rapid,...nongenomic...steroid...signalling...[1].Baf...did...not...interfere...with...transport...of...HRP...to...MPR-labeled...late...endosomes,...but...nearly...completely...abrogated...transport...to...cathepsin...D-labeled...lysosomes...[21].When...the...cells...were...treated...with...the...lysosomotropic...amine...primaquine,...binding...of...anti-MPR...to...the...cells...in...culture...was...reduced...by...half...[19].In...a...second...approach,...sections...of...formalin-fixed...breast...biopsy...specimens...were...probed...with...biotinylated...MPR...[22].The...phosphorylated...MPR...300-CT...was...cross-linked...by...means...of...bis(sulfosuccinimidyl)suberate...mainly...to...a...cytosolic...protein...of...35...kDa...(referred...to...as...TIP...35)...and...to...35-...and...91-kDa...proteins...salt-washed...from...bovine...brain...membranes...[23]....Welcome..to..WikiGenes!..If..you..are..familiar..with..the..subject..of..this..article,..you..can..contribute..to..this..open..access..knowledge..base..by..deleting..incorrect..information,..restructuring..or..completely..rewriting..any..text...doi:10.1111/j.1471-4159.2005.03127.x....coli..mPR..which..suppressed..the..rapid..progesterone-initiated..Ca2+..increase..in..sperm..[1].We..report..here..that..the..Hpr6.6..protein..regulates..the..response..to..oxidative..damage..in..breast..cancer..cells..[2].After..the..start..of..the..nationwide..measles,..parotitis,..and..rubella..(MPR)..vaccination..programme..in..1982..in..Finland,..encephalitides..associated..with..these..viruses..seem..to..have..totally..vanished..[3].Addition..of..the..antibodies..to..the..medium..of..Morris..hepatoma..7777..cells,..which..express..only..the..Mr..46,000..MPR,..resulted..in..a..decreased..intracellular..retention..and..increased..secretion..of..newly..synthesized..lysosomal..enzymes..[4].At..follow-up,..a..steeper..correlation..was..found..between..MPR..and..minimal..stenosis..diameter..(MPR1:..slope,..0.52..versus..0.91;..MPR2:..slope,..1.48..versus..1.95)..and..between..MaxFR..and..net..lumen..gain..(slope,..0.78..versus..1.27)..[5].PGRMC1's..role..in..regulating..the..viability..of..ovarian..cancers..was..assessed..by..overexpressing..PGRMC1,..depleting..PGRMC1..using..small..interfering..RNA,..and..attenuating..PGRMC1's..action..with..a..blocking..antibody..[6]...PGRMC1...and...its...binding...partner,...plasminogen...activator...inhibitor...RNA-binding...protein-1...(PAIRBP1),...were...detected...in...human...granulosa/luteal...cells...[17].Here...we...show...that...expression...of...mPR-cDNA...in...CHO...cells...leads...to...increased...microsomal...progesterone...binding...[1].In...control...fibroblasts...that...express...both...types...of...MPR,...the...secretion-recapture...pathway...is...of...minor...importance...[18].MPR...and...lysosomal...enzymes...were...also...found...in...coated...pits...of...the...plasma...membrane...[19].On...this...basis,...it...has...been...proposed...that...cells...lacking...MPR...are...poor...targets...for...cytotoxic...lymphocytes...that...mediate...allograft...rejection...or...tumor...immune...surveillance...[20]....References[edit]..Biochemistry...^...a...b...c...d...Peluso...JJ,...Romak...J,...Liu...X...(Feb...2008)...."Transcriptional.activation.of.the.membrane-bound.progesterone.receptor.(mPR).by.dioxin,.in.endocrine-responsive.tissues"..

 

Interactions.Go.to.the.top.of.the.page.Help.Products.Interactant.Other.Gene.Complex.Source.Pubs.Description.General.gene.information.Go.to.the.top.of.the.page.Help.Markers.PGRMC1.(e-PCR)UniSTS:498205.RH12552.(e-PCR)UniSTS:69995.RH70157.(e-PCR)UniSTS:18584.G32326.(e-PCR)UniSTS:116919.A006D23.(e-PCR)UniSTS:35835.Homology.Homologs.of.the.PGRMC1.gene:.The.PGRMC1.gene.is.conserved.in.Rhesus.monkey,.dog,.cow,.mouse,.rat,.chicken,.zebrafish,.fruit.fly,.mosquito,.C.elegans,.S.cerevisiae,.K.lactis,.E.gossypii,.S.pombe,.M.oryzae,.N.crassa,.and.frog..doi:10.1038/ncomms1386...Chu..UB,..et..al..."Regulation.of.ovarian.cancer.cell.viability.and.sensitivity.to.cisplatin.by.progesterone.receptor.membrane.component-1"..PMC2219306..Other.interactions.of.PGRMC1..These.may.include.binding.to.Insig.(insulin-induced.gene),[13].which.regulates.cholesterol.synthesis.[14]..doi:10.1210/en.2007-1050....

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